Synthetic Cell Biology

CRY2olig clustering tool

In a yeast genetic screen, we identified a mutant version of CRY2 that undergoes pronounced self-self association upon light exposure, forming higher-order oligomers.

DisCo, a method to inducibly disrupt biomolecular condensates

DisCo (Dissociation of Condensates) is a method we developed in which recruitment of a monovalent ligand into a condensate induces its disruption.

See: Hernandez et al., 2021.

Chemical tools to reversibly form condensates

We have developed a new platform, “BTBolig” allowing users to form and dissolve biomolecular condensates with a chemical ligand. The system uses the BTB domain from BCL-6 and its ligands BI-3802 and BI-3012 for ligand-induced condensate formation. See: https://rdcu.be/dvqwl for more details.